Analgesic and anti-inflammatory activities of 11-O-galloylbergenin

  • J Ethnopharmacol. 2010 Sep 15;131(2):502-4. doi: 10.1016/j.jep.2010.06.040.
Mohammad Arfan  1 ,  Hazrat Amin ,  Nematullah Khan ,  Inamullah Khan ,  Muhammad Saeed ,  Muhammad Azim Khan ,  Fazal-ur-Rehman
Affiliations
  • 1. Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan.
PMID: 20603209 DOI: 10.1016/j.jep.2010.06.040
Abstract

Aims of the study: Current study was designed to explore the analgesic and anti-inflammatory effects of a constituent isolated from Mallotus philippinensis, in order to validate its folk use.

Materials and methods: 11-O-galloylbergenin was isolated from ethanolic extract of Mallotus philippinensis. Analgesic and anti-inflammatory activities of the test compound were assessed using formalin test and carrageenan-induced paw edema models.

Results: 11-O-galloylbergenin showed significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats. Similarly, 11-O-galloylbergenin exhibited significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.

Conclusion: 11-O-galloylbergenin has demonstrated its significant potential to be further investigated for its discovery as a new lead compound for management of pain and inflammation.

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