Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic

  • J Nat Prod. 2010 Sep 24;73(9):1461-4. doi: 10.1021/np100344u.
Patrícia Bezerra Gomes  1 ,  Markus Nett ,  Hans-Martin Dahse ,  Christian Hertweck
Affiliations
  • 1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse, 07745 Jena, Germany.
PMID: 20715808 DOI: 10.1021/np100344u
Abstract

Chemical profiling of a Streptomyces griseus strain isolated from an old building with Moisture damage led to the discovery of two novel phenoxazinones, chandrananimycin D and pitucamycin , along with the known grixazone B. Pitucamycin represents an unprecedented hybrid molecule composed of a phenoxazinone and an enaminomycin-like epoxyquinone moiety.

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