Kinesin-14: the roots of reversal
- BMC Biol. 2010 Aug 16:8:107. doi: 10.1186/1741-7007-8-107.
Affiliations
- 1. Centre for Mechanochemical Cell Biology, Warwick University Medical School, Gibbet Hill, Coventry CV4 7AL, UK. [email protected]
PMID: 20731883
DOI: 10.1186/1741-7007-8-107
Abstract
Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to Other kinesins. Work on the still-enigmatic Kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins.