Pyridone and tetramic acid alkaloids from the spider pathogenic fungus Torrubiella sp. BCC 2165

  • J Nat Prod. 2010 Dec 27;73(12):2057-60. doi: 10.1021/np100492j.
Masahiko Isaka  1 ,  Panida Chinthanom ,  Sumalee Supothina ,  Punsa Tobwor ,  Nigel L Hywel-Jones
Affiliations
  • 1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, Thailand. [email protected]
PMID: 21090800 DOI: 10.1021/np100492j
Abstract

Torrubiellones A-D (1-4), new pyridone and tetramic acid Alkaloids, were isolated from the spider pathogenic fungus Torrubiella sp. BCC 2165. Torrubiellone A (1) exhibited antimalarial activity with an IC(50) value of 8.1 μM, while it showed very weak cytotoxic activity.