Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma

  • Eur J Med Chem. 2011 Jan;46(1):175-82. doi: 10.1016/j.ejmech.2010.10.033.
Seif-Eldin N Ayyad  1 ,  Mohamed S Makki ,  Nazeeha S Al-Kayal ,  Salim A Basaif ,  Kalid O El-Foty ,  Abdullah M Asiri ,  Walied M Alarif ,  Farid A Badria
Affiliations
  • 1. Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia. [email protected]
PMID: 21130542 DOI: 10.1016/j.ejmech.2010.10.033
Abstract

Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8β-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new Diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9 have potent activity against DNA damage, cytotoxicity against WI-38, HepG2, and MCF-7 cell lines, and antioxidant using ABTS and erythrocytes hemolysis.