Cytotoxic amide alkaloids from Piper boehmeriaefolium

  • J Nat Prod. 2011 Jan 28;74(1):45-9. doi: 10.1021/np100606u.
Gui-Hua Tang  1 ,  Dong-Mei Chen ,  Bei-Ying Qiu ,  Li Sheng ,  Yue-Hu Wang ,  Guang-Wan Hu ,  Fu-Wei Zhao ,  Li-Juan Ma ,  Huan Wang ,  Qiao-Qin Huang ,  Jin-Jin Xu ,  Chun-Lin Long ,  Jia Li
Affiliations
  • 1. Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 21158422 DOI: 10.1021/np100606u
Abstract

Eight new amide Alkaloids (1-8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC(50) value of 2.7 μg/mL.