Activity of Debaryomyces hansenii UFV-1 α-galactosidases against α-D-galactopyranoside derivatives

  • Carbohydr Res. 2011 Apr 1;346(5):602-5. doi: 10.1016/j.carres.2011.01.024.
Pollyanna A Viana  1 ,  Sebastião T de Rezende ,  Arianne de A Alves ,  Rozângela M Manfrini ,  Ricardo J Alves ,  Marcelo P Bemquerer ,  Marcelo M Santoro ,  Valéria M Guimarães
Affiliations
  • 1. BIOAGRO, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil.
PMID: 21345419 DOI: 10.1016/j.carres.2011.01.024
Abstract

α-D-Galactopyranosides were synthesized and their inhibitory activities toward the Debaryomyces hansenii UFV-1 extracellular and intracellular α-galactosidases were evaluated. Methyl α-D-galactopyranoside was the most potent inhibitor compared to the Others tested, with K(i)(') values of 0.82 and 1.12 mmolL(-1), for extracellular and intracellular Enzymes, respectively. These results indicate that the presence of a hydroxyl group in the C-6 position of α-D-galactopyranoside derivatives is important for the recognition by D. hansenii UFV-1 α-galactosidases.

Products