One-pot synthesis of pyrazoline derivatised carbazoles as antitubercular, anticancer agents, their DNA cleavage and antioxidant activities

  • Eur J Med Chem. 2011 Sep;46(9):4366-73. doi: 10.1016/j.ejmech.2011.07.007.
Tasneem Taj  1 ,  Ravindra R Kamble ,  T M Gireesh ,  Raveendra K Hunnur ,  Sheetal B Margankop
Affiliations
  • 1. PG Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580 003, India.
PMID: 21802797 DOI: 10.1016/j.ejmech.2011.07.007
Abstract

Novel tricyclic carbazoles 4a-k were synthesized in one-pot employing sydnone derivatives 3a-k as masked hydrazines by the ring transformation in presence of conc. HCl and cyclohexanone. The title compounds were screened for anti-tubercular, anti Cancer, DNA cleavage, antioxidant activity. MIC, GI50, LC50, TGI were evaluated. The title compounds have exhibited significant antitubercular, DNA cleavage and antioxidant activities and partial Anticancer activity.