Antioxidant flavonoids from Epimedium wushanense

  • Fitoterapia. 2012 Jan;83(1):44-8. doi: 10.1016/j.fitote.2011.09.010.
Hui-fang Li  1 ,  Xiang-yu Guan ,  Wen-zhi Yang ,  Ke-di Liu ,  Min Ye ,  Chao Sun ,  Shuang Lu ,  De-an Guo
Affiliations
  • 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
PMID: 21968061 DOI: 10.1016/j.fitote.2011.09.010
Abstract

Two new Flavonoids, wushanicaritin (1) and wushankaempferol (2), along with 24 known Flavonoids were isolated from the whole herb of Epimedium wushanense T.S. Ying (Berberidaceae). On the basis of NMR and ESI-MS spectroscopic analysis, structures of compounds 1 and 2 were elucidated as 8-γ-hydroxy-γ,γ-dimethylpropyl-3,5,7-trihydroxy-4'- methoxyflavone and kaempferol 3-O-α-l-[2,3-di-O-β-D-(6-E-p-coumaroyl) glucopyranosyl]-rhamnopyranosyl-7-O-α-L-rhamnopyranoside, respectively. DPPH radical scavenging activity tests indicated that 1 (IC(50) 35.3 μM) exhibited antioxidant activity comparable to Vitamin C (IC(50) 32.0 μM), while 2 (IC(50) 443.7 μM) showed weak activity.

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