Hyaluronidase inhibitors from Keiskea japonica

  • Chem Pharm Bull (Tokyo). 2012;60(1):121-8. doi: 10.1248/cpb.60.121.
Toshihiro Murata  1 ,  Toshio Miyase ,  Fumihiko Yoshizaki
Affiliations
  • 1. Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. [email protected]
PMID: 22223383 DOI: 10.1248/cpb.60.121
Abstract

An extract of Keiskea japonica MIQ. showed an inhibitory effect on hyaluronidase activity. From the extract, four new Phenylpropanoids, two new maltol glycosides, two new monoterpene glycosides, and two new phenolic compounds were isolated together with 19 known compounds. Among these constituents, two Phenylpropanoids and a flavone glucuronide were revealed as hyaluronidase inhibitors.

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