Phaeosphaerins A-F, cytotoxic perylenequinones from an endolichenic fungus, Phaeosphaeria sp

  • J Nat Prod. 2012 Feb 24;75(2):142-7. doi: 10.1021/np200614h.
Gang Li  1 ,  Haiying Wang ,  Rongxiu Zhu ,  Lingmei Sun ,  Lining Wang ,  Ming Li ,  Yaoyao Li ,  Yongqing Liu ,  Zuntian Zhao ,  Hongxiang Lou
Affiliations
  • 1. Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
PMID: 22276650 DOI: 10.1021/np200614h
Abstract

Six novel phototoxins, phaeosphaerins A-F, together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeria sp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill Cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.