The first stereoselective total synthesis of (Z)-cryptomoscatone D2, a natural G₂ checkpoint inhibitor

  • Bioorg Med Chem Lett. 2012 Apr 1;22(7):2415-7. doi: 10.1016/j.bmcl.2012.02.025.
Gandolla Chinna Reddy  1 ,  Penagaluri Balasubramanyam ,  N Salvanna ,  Thummala Sreenivasulu Reddy ,  Biswanath Das
Affiliations
  • 1. Organic Chemistry Division-I, Indian Institute of Chemical Technology (CSIR), Hyderabad 500 007, India.
PMID: 22405831 DOI: 10.1016/j.bmcl.2012.02.025
Abstract

The first stereoselective synthesis of (Z)-cryptomoscatone D2, a naturally occurring G(2) checkpoint inhibitor, was accomplished using propane-1,3-diol as the starting material. The Maruoka asymmetric allylation, ring closing metathesis and the hydrogenation of the triple bond employing Lindlar's catalyst were involved as the key steps.

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