Synthesis of nucleoside phosphosulfates

  • Bioorg Med Chem Lett. 2012 Jun 1;22(11):3661-4. doi: 10.1016/j.bmcl.2012.04.039.
Joanna Kowalska  1 ,  Agnieszka Osowniak ,  Joanna Zuberek ,  Jacek Jemielity
Affiliations
  • 1. Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Warsaw, Poland.
PMID: 22572581 DOI: 10.1016/j.bmcl.2012.04.039
Abstract

We describe an efficient and scalable procedure for the chemical synthesis of nucleoside 5'-phosphosulfates (NPS) from nucleoside 5'-phosphorimidazolides and sulfate bis(tributylammonium) salt. Using this method we obtained various NPS with yields ranging from 70-90%, including adenosine 5'-phosphosulfate (APS) and 2',3'-cyclic precursor of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), which are the key intermediates in the assimilation and metabolism of sulfur in all living organisms.

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