Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

  • Bioorg Med Chem Lett. 2013 Jun 1;23(11):3385-8. doi: 10.1016/j.bmcl.2013.03.077.
Longhu Zhou  1 ,  Franck Amblard ,  Hongwang Zhang ,  Tamara R McBrayer ,  Mervi A Detorio ,  Tony Whitaker ,  Steven J Coats ,  Raymond F Schinazi
Affiliations
  • 1. Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Decatur, GA 30033, USA.
PMID: 23623492 DOI: 10.1016/j.bmcl.2013.03.077
Abstract

The synthesis of new ribo and 2'-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells.