Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity

  • J Nat Prod. 2013 Jul 26;76(7):1248-53. doi: 10.1021/np400082g.
Luo-Sheng Wan  1 ,  Qiu-Xia Min ,  Yong-Long Wang ,  Yao-Dong Yue ,  Jia-Chun Chen
Affiliations
  • 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
PMID: 23805995 DOI: 10.1021/np400082g
Abstract

Ten new xanthone glycosides, kouitchensides A-J (1-10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis. The structures of these glycosides were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compounds 2, 4, 5, 6, 11, 12, and 13 (IC50 values in the range 126 to 451 μM) displayed more potent inhibitory effects against α-glucosidase activity than the positive control, acarbose (IC50 value of 627 μM).

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