Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened

  • ChemMedChem. 2013 Aug;8(8):1261-5. doi: 10.1002/cmdc.201300217.
Stefan Peukert  1 ,  Feng He ,  Miao Dai ,  Rui Zhang ,  Yingchuan Sun ,  Karen Miller-Moslin ,  Michael McEwan ,  Bharat Lagu ,  Kate Wang ,  Naeem Yusuff ,  Aaron Bourret ,  Arun Ramamurthy ,  Wieslawa Maniara ,  Adam Amaral ,  Anthony Vattay ,  Anlai Wang ,  Ribo Guo ,  Jing Yuan ,  John Green ,  Juliet Williams ,  Silvia Buonamici ,  Joseph F Kelleher 3rd ,  Marion Dorsch
Affiliations
  • 1. Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. [email protected].
PMID: 23821351 DOI: 10.1002/cmdc.201300217
Keywords
antitumor agents; hedgehog signaling; medicinal chemistry; pyridazines; smoothened inhibitors.
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-18636
    LEQ506
    98.92%, Smo Inhibitor
    target: Smo
    Research Areas: Cancer