Trichinenlides A-T, mexicanolide-type limonoids from Trichilia sinensis

  • J Nat Prod. 2013 Oct 25;76(10):1872-80. doi: 10.1021/np400408s.
Jin-Biao Xu  1 ,  Yuan Lin ,  Shi-Hui Dong ,  Fei Wang ,  Jian-Min Yue
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
PMID: 24094143 DOI: 10.1021/np400408s
Abstract

Twenty new mexicanolide-type limonoids, namely, trichinenlides A-T (1-20), and 11 known analogues were isolated from the leaves and twigs of Trichilia sinensis. Trichinenlides B (2) and C (3) and heytrijunolide D exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 2.85, 1.88, and 3.33 μM, respectively.