Identification of mureidomycin analogues and functional analysis of an N-acetyltransferase in napsamycin biosynthesis

  • Chembiochem. 2013 Nov 25;14(17):2248-55. doi: 10.1002/cbic.201300287.
Xiaoyu Tang  1 ,  Marcel Gross ,  Yunying Xie ,  Andreas Kulik ,  Bertolt Gust
Affiliations
  • 1. Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, 72076 Tübingen (Germany).
PMID: 24115404 DOI: 10.1002/cbic.201300287
Abstract

Antibiotic abundance: Several new uridyl peptide Antibiotics were identified from a heterologous producer strain containing the mureidomycin/napsamycin biosynthetic gene cluster by using HRMS and LC-ESI-MS/MS. Analysis of the new compounds and the corresponding gene cluster revealed NpsB, an N-acetyltransferase, to be responsible for acetylation of the uridyl peptide Antibiotic.

Keywords
N-acetylation; biosynthesis; heterologous expression; uridyl peptide antibiotics.
Products