The effect of safflower yellow on spinal cord ischemia reperfusion injury in rabbits

  • Oxid Med Cell Longev. 2013;2013:692302. doi: 10.1155/2013/692302.
Daiwei Zhou  1 ,  Bingbing Liu  1 ,  Xiaoshan Xiao  1 ,  Peng Dai  2 ,  Songmei Ma  1 ,  Weihua Huang  1
Affiliations
  • 1. Department of Anesthesiology, Guangdong No. 2 Provincial People's Hospital, Guangdong Provincial Emergency Hospital, Guangzhou, Guangdong Province 0086 510317, China.
  • 2. Department of Anesthesiology, Foshan First People's Hospital, Guangdong Province 0086 510317, China.
PMID: 24381717 DOI: 10.1155/2013/692302
Abstract

Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and plasma levels of lipid peroxidation reactioin and neuronal morphologic changes. SCIRI remarkably affected the functional activities of the hind limbs and activated lipid peroxidation reaction. SY could attenuate Apoptosis and SCIRI by enhancing Bcl-2 expression and inhibiting Bax and Caspase-3 activation.

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