Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis

  • Org Lett. 2014 Feb 7;16(3):928-31. doi: 10.1021/ol403657r.
Fakir Shahidullah Tareq  1 ,  Min Ah Lee ,  Hyi-Seung Lee ,  Yeon-Ju Lee ,  Jong Seok Lee ,  Choudhury M Hasan ,  Md Tofazzal Islam ,  Hee Jae Shin
Affiliations
  • 1. Department of Marine Biotechnology, University of Science and Technology , Republic of Korea.
PMID: 24502521 DOI: 10.1021/ol403657r
Abstract

Gageotetrins A-C (1-3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1-3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1-3 displayed good antimicrobial activities with MIC values of 0.01-0.06 μM. However, these compounds failed to register any cytotoxicity (GI50 > 30 μg/ml) against human Cancer cell lines.

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