Efficacy of afoxolaner against Ixodes scapularis ticks in dogs

  • Vet Parasitol. 2014 Apr 2;201(3-4):223-5. doi: 10.1016/j.vetpar.2014.02.015.
Elizabeth B Mitchell  1 ,  John W McCall  2 ,  S Theodore Chester  3 ,  Diane Larsen  3
Affiliations
  • 1. Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA. Electronic address: [email protected].
  • 2. TRS Labs, Inc., PO Box 5112, Athens, GA, USA.
  • 3. Merial Limited, 3239 Satellite Boulevard, Duluth, GA 30096, USA.
PMID: 24685321 DOI: 10.1016/j.vetpar.2014.02.015
Abstract

Efficacy of afoxolaner, a novel isoxazoline Insecticide/acaricide, against Ixodes scapularis was evaluated in a laboratory study. One day prior to treatment, beagle dogs (n=16) were infested with 50 unfed wild adult ticks. Repeat infestations were performed weekly for four additional weeks. The number of live ticks remaining on each dog was determined 48 h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.

Keywords
Afoxolaner; Dogs; Ixodes scapularis; Oral; Ticks.
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