Neoflavonoids as potential osteogenic agents from Dalbergia sissoo heartwood

  • Bioorg Med Chem Lett. 2014 Jun 15;24(12):2664-8. doi: 10.1016/j.bmcl.2014.04.056.
Padam Kumar  1 ,  Priyanka Kushwaha  2 ,  Vikram Khedgikar  2 ,  Jyoti Gautam  2 ,  Dharmendra Choudhary  2 ,  Divya Singh  2 ,  Ritu Trivedi  2 ,  Rakesh Maurya  3
Affiliations
  • 1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • 2. Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • 3. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India. Electronic address: [email protected].
PMID: 24803361 DOI: 10.1016/j.bmcl.2014.04.056
Abstract

The present study was undertaken to investigate and rationalize the in vitro antiosteoporotic activity of neoflavonoids, isolated from Dalbergia sissoo heartwood. Neoflavonoids were isolated using extensive column chromatography and identified as dalsissooal (1) a new compound and cearoin (2), dalbergin (3), 4-methoxy dalbergion (4), dalbergiphenol (5), dalbergichromene (6), methyl dalbergin (7) and latinone (8) as known compounds by comparison their spectroscopic data with those reported in the literature. Among the screened compounds, compounds 1, 3, 5-8 significantly increased proliferation as assessed by Alkaline Phosphatase activity and mineralization in calvarial osteoblast cells.

Keywords
Dalbergia sissoo; Neoflavanoids; Osteoblast; Osteoporosis.
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