Nine new farnesylphenols from the basidiomycete albatrellus caeruleoporus

  • Nat Prod Bioprospect. 2014 Apr;4(2):119-28. doi: 10.1007/s13659-014-0015-5.
Liang-Yan Liu  1 ,  Zheng-Hui Li  2 ,  Gang-Qiang Wang  2 ,  Kun Wei  2 ,  Ze-Jun Dong  2 ,  Tao Feng  2 ,  Gen-Tao Li  2 ,  Yan Li  2 ,  Ji-Kai Liu  2
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan China ; University of the Chinese Academy of Sciences, Beijing, 100049 China.
  • 2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan China.
PMID: 24858140 DOI: 10.1007/s13659-014-0015-5
Abstract

Nine previously-unreported farnesylphenols, involving eight neogrifolin derivatives (1-8) and one grifolin analogue (9), together with three known compounds, were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus. Their structures were elucidated as (S)-17-hydroxy-18,20-ene-neogrifolin (1), (S)-18,19-dihydroxyneogrifolin (2), (S)-9-hydroxy-10,22-ene-neogrifolin (3), (9S,10R)-6,10-epoxy-9-hydroxyneo grifolin (4), (9S,10R)-6,9-epoxy-10-hydroxyneogrifolin (5), (-)-13,14-dihydroxyneogrifolin (6), albatrelin G (7), albatrelin H (8), and one grifolin analogue, (S)-10-hydroxygrifolin (9), grifolin (10), neogrifolin (11), and albatrellin (12) by extensive spectroscopic analyses and chemical methods. Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.

Keywords
Albatrellus caeruleoporus; Farnesylphenols; Mushroom; Polyporaceae.
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