Peganumine A, a β-carboline dimer with a new octacyclic scaffold from Peganum harmala
- Org Lett. 2014 Aug 1;16(15):4028-31. doi: 10.1021/ol501856v.
Affiliations
- 1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, Liaoning, P. R. China.
PMID: 25054213
DOI: 10.1021/ol501856v
Abstract
Peganumine A (1), a new dimeric β-carboline alkaloid characterized by a unique 3,9-diazatetracyclo[6.5.2.0(1,9).0(3,8)]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 μM.
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