Cytotoxic and Antibacterial Quinone Sesquiterpenes from a Myrothecium Fungus

  • J Nat Prod. 2014 Aug 22;77(8):1791-9. doi: 10.1021/np500142g.
Ying Fu  1  2 ,  Ping Wu  1 ,  Jinghua Xue  1 ,  Xiaoyi Wei  1
Affiliations
  • 1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
  • 2. University of Chinese Academy of Sciences , Yuquanlu 19A, Beijing 100049, People's Republic of China.
PMID: 25089733 DOI: 10.1021/np500142g
Abstract

Six new quinone Sesquiterpenes, myrothecols A-F (1-6), and hymenopsin B (7) were isolated from cultures of Myrothecium sp. SC0265 by bioassay-guided fractionation. Their structures were elucidated on the basis of 1D and 2D NMR and MS data. The absolute configurations of the new compounds were assigned by CD/TDDFT calculations, and that of and hymenopsin B was confirmed by X-ray diffraction analysis. Compounds 1-5 and hymenopsin demonstrated cytotoxic activity against human carcinoma A549, HeLa, and HepG2 cells. Compounds 1-5 also exhibited Antibacterial activity against Staphylococcus aureus and Bacillus cereus.