Steroidal saponins from Tribulus terrestris

  • Phytochemistry. 2014 Nov:107:182-9. doi: 10.1016/j.phytochem.2014.08.003.
Li-Ping Kang  1 ,  Ke-Lei Wu  2 ,  He-Shui Yu  2 ,  Xu Pang  3 ,  Jie Liu  4 ,  Li-Feng Han  4 ,  Jie Zhang  3 ,  Yang Zhao  3 ,  Cheng-Qi Xiong  3 ,  Xin-Bo Song  4 ,  Chao Liu  3 ,  Yu-Wen Cong  3 ,  Bai-Ping Ma  5
Affiliations
  • 1. Beijing Institute of Radiation Medicine, Beijing 100850, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; State Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
  • 2. Beijing Institute of Radiation Medicine, Beijing 100850, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • 3. Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • 4. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • 5. Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: [email protected].
PMID: 25172515 DOI: 10.1016/j.phytochem.2014.08.003
Abstract

Sixteen steroidal saponins, including seven previously unreported compounds, were isolated from Tribulus terrestris. The structures of the saponins were established using 1D and 2D NMR spectroscopy, mass spectrometry, and chemical methods. They were identified as: 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-2α,3β,22α,26-tetrol-12-one (terrestrinin C), 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-22α,26-diol-3,12-dione (terrestrinin D), 26-O-β-d-glucopyranosyl-(25S)-furost-4-en-22α,26-diol-3,6,12-trione (terrestrinin E), 26-O-β-d-glucopyranosyl-(25R)-5α-furostan-3β,22α,26-triol-12-one (terrestrinin F), 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-12β,22α,26-triol-3-one (terrestrinin G), 26-O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl-(25R)-furost-4-en-22α,26-diol-3,12-dione (terrestrinin H), and 24-O-β-d-glucopyranosyl-(25S)-5α-spirostan-3β,24β-diol-12-one-3-O-β-d-glucopyranosyl-(1→4)-β-d-galactopyranoside (terrestrinin I). The isolated compounds were evaluated for their platelet aggregation activities. Three of the known saponins exhibited strong effects on the induction of platelet aggregation.

Keywords
Liliaceae; Platelet aggregation; Steroidal saponins; Terrestrinins C–I; Tribulus terrestris.
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