Structure of diarylheptanoids with antiallergic activity from the rhizomes of Curcuma comosa

  • J Nat Med. 2015 Jan;69(1):142-7. doi: 10.1007/s11418-014-0870-8.
Takahiro Matsumoto  1 ,  Seikou Nakamura ,  Katsuyoshi Fujimoto ,  Tomoe Ohta ,  Keiko Ogawa ,  Masayuki Yoshikawa ,  Eri Onishi ,  Masashi Fukaya ,  Hisashi Matsuda
Affiliations
  • 1. Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
PMID: 25300344 DOI: 10.1007/s11418-014-0870-8
Abstract

The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit the release of β-hexosaminidase as a maker of degranulation from rat basophil leukemia (RBL-2H3) cells. Two new diarylheptanoids, diarylcomosols IV and V, were isolated from the methanolic extract. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The isolated diarylheptanoids showed inhibitory activity, and the structural requirements of the active constituents for the inhibition were clarified.

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