Limonoid and Steroidal Saponin from Azadirachta indica

  • Nat Prod Bioprospect. 2014 Dec;4(6):335-40. doi: 10.1007/s13659-014-0042-2.
Lu Liu  1  2 ,  Yun-Li Zhao  1 ,  Gui-Guang Cheng  3 ,  Ying-Ying Chen  1  2 ,  Xu-Jie Qin  1  2 ,  Chang-Wei Song  1  2 ,  Xing-Wei Yang  1  2 ,  Ya-Ping Liu  4 ,  Xiao-Dong Luo  5
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
  • 2. University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • 3. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
  • 4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. [email protected].
  • 5. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. [email protected].
PMID: 25381190 DOI: 10.1007/s13659-014-0042-2
Abstract

A new limonoid, 17-(5-methoxy-2-oxofuran-3-yl)-28-deoxonimbolide (1), and a new C21 steroidal saponin, 2α,4α-dihydroxy-pregn-5-en-16-one-3α-O-D-glucopyranoside (2), together with 11 known compounds were isolated from the methanol extract of the leaves of Azadirachta indica. The structures were elucidated by means of spectroscopic analysis and putative biosynthetic origins. All the compounds were evaluated for their Antibacterial activities against six Bacterial strains.

Keywords
Antibacterial activities; Azadirachta indica; Limonoid; Steroidal saponin.
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