Tuning macrocycles to design 'turn-on' fluorescence probes for manganese(II) sensing in live cells

  • Chem Commun (Camb). 2015 Feb 14;51(13):2605-8. doi: 10.1039/c4cc09542a.
Subha Bakthavatsalam  1 ,  Anindita Sarkar ,  Ananya Rakshit ,  Shubhi Jain ,  Amit Kumar ,  Ankona Datta
Affiliations
  • 1. Department of Chemical Sciences, Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Colaba, Mumbai-400005, India. [email protected].
PMID: 25572103 DOI: 10.1039/c4cc09542a
Abstract

We tune the coordination environment of macrocyclic ligands to design two novel fluorescence sensors for Mn(2+). The BODIPY-based Mn(2+) sensor M1 affords an excellent, 52 fold, fluorescence 'turn-on' response despite the paramagnetic nature of Mn(2+). The lipophilic probe is cell-permeable and confocal imaging demonstrates that the sensor distinctly detects Mn(2+) within live cells.

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