Anthocephaline, a new indole alkaloid and cadambine, a potent inhibitor of DNA topoisomerase IB of Leishmania donovani (LdTOP1LS), isolated from Anthocephalus cadamba

  • Nat Prod Commun. 2015 Feb;10(2):297-9.
Ashish Kumar ,  Somenath Roy Chowdhury ,  Kumar Kalyan Jatte ,  Tulika Chakrabarti ,  Hemanta K Majumder ,  Tarun Jha ,  Sibabrata Mukhopadhyay
PMID: 25920266
Abstract

Chemical investigation of the stem bark of Anthocephalus cadamba has resulted in the isolation of anthocephaline (1), a new indole alkaloid, along with strictosamide (2), vincosamide (3) and cadambine (4). The structures of the isolated Alkaloids (1-4) were established by detailed 2D NMR spectral analysis. Cadambine (4) exhibited potent DNA Topoisomerase IB inhibitory activity.

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