Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities

  • Molecules. 2015 Aug 14;20(8):14879-88. doi: 10.3390/molecules200814879.
Bao-Bao Zhang  1 ,  Bai-Qiu He  2 ,  Jian-Bo Sun  3 ,  Biao Zeng  1 ,  Xiao-Ji Shi  4 ,  Yong Zhou  5 ,  Ying Niu  6 ,  Shi-Qi Nie  7 ,  Feng Feng  8 ,  Yan Liang  9 ,  Fei-Hua Wu  10
Affiliations
  • 1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
  • 2. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
  • 3. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
  • 4. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
  • 5. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
  • 6. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
  • 7. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
  • 8. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
  • 9. Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing 210018, China. [email protected].
  • 10. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. [email protected].
PMID: 26287144 DOI: 10.3390/molecules200814879
Abstract

A new skeleton of diterpenoid, 1,2,3,4,4α,9,10,10α-octahydro-(4α-hydroxyymethyl) -1,1-dimethyl-9-(1-methylethyl)-(2S,3S,4αR,9R,10αS)-2,3,5,7-phenanthrenetertrol, named plebeianiol A (1), along with four known Diterpenoids (2-5), were isolated from Salvia plebeia R. Br. Their structures were determined on the basis of spectral analysis. In the bioactivity tests, compounds 1, 2 and 5 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities with IC50 values of 20.0-29.6 µM. In addition, these three compounds had significant inhibitory effects on Reactive Oxygen Species (ROS) production in lipopolysaccharide (LPS)-induced macrophages. Compounds 1-3 inhibited nitric oxide (NO) production in LPS-induced macrophages with IC50 values of 18.0-23.6 µM. These results showed that compounds 1, 2 had significant antioxidant and anti-inflammatory activities and might provide basis for the treatment of diseases associated with oxidative lesions and inflammation.

Keywords
Salvia plebeia; anti-inflammatory activity; antioxidant activity; diterpenoids.
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