Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide

  • Bioorg Med Chem Lett. 2015 Oct 15;25(20):4572-5. doi: 10.1016/j.bmcl.2015.08.057.
Hongmei Zhao  1 ,  Guangzhi Zeng  2 ,  Simeng Zhao  2 ,  Junju Xu  3 ,  Lingmei Kong  2 ,  Yan Li  2 ,  Ninghua Tan  2 ,  Shengchao Yang  4
Affiliations
  • 1. Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials, Yunnan Agricultural University, Kunming 650201, PR China; School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China.
  • 2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
  • 3. Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials, Yunnan Agricultural University, Kunming 650201, PR China. Electronic address: [email protected].
  • 4. Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials, Yunnan Agricultural University, Kunming 650201, PR China.
PMID: 26351042 DOI: 10.1016/j.bmcl.2015.08.057
Abstract

Three new labdane diterpenes, hedylongnoids A (1), B (2) and C (3), were isolated from the rhizomes of Hedychium longipetalum, together with three known ones yunnancoronarin A (4), hedyforrestin C (5) and hedyforrestin B (6). Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Compounds 1-6 exhibited inhibitory effects against nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages with IC50 values ranging from 0.56 to 7.50 μg/ml, and 3-6 showed cytotoxicities against Cancer cell lines SGC-7901 and Hela with IC50 values ranging from 6.21 to 14.53 μg/ml and from 6.58 to 14.83 μg/ml, respectively.

Keywords
Cytotoxicity; Hedychium longipetalum; Inhibition of NO production; Labdane diterpenes; Zingiberaceae.