Chalcane-stilbene conjugates and oligomeric flavonoids from Chinese Dragon's Blood produced from Dracaena cochinchinensis

  • Phytochemistry. 2015 Nov;119:76-82. doi: 10.1016/j.phytochem.2015.09.009.
Qian Hao  1 ,  Yoshinori Saito  1 ,  Yosuke Matsuo  1 ,  Hai-Zhou Li  2 ,  Takashi Tanaka  3
Affiliations
  • 1. Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-Machi, Nagasaki 852-8521, Japan.
  • 2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Yunnan 650500, People's Republic of China.
  • 3. Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-Machi, Nagasaki 852-8521, Japan. Electronic address: [email protected].
PMID: 26452504 DOI: 10.1016/j.phytochem.2015.09.009
Abstract

A detailed chemical investigation of Chinese Dragon's Blood, which is a traditional medicine produced form the red resin of Dracaena cochinchinensis, yielded two chalcane-stilbene conjugates, named cochinchinenenes G and H, together with 25 known compounds. The structures of these compounds were determined by spectroscopic examination. HPLC analysis of the resin indicated that the major constituents were a complex mixture of oligomeric Polyphenols, which were detected as a broad hump on the base line of a HPLC chromatogram. (13)C NMR analysis indicated that the oligomers were mainly composed of oxygenated chalcane units. This suggestion was supported by the results of a thiol degradation experiment with mercaptoethanol, which yielded a thioether of 4-[(4-hydroxyphenyl)propyl]-3-methoxyphenol. Furthermore, methylation followed by electrospray ionization mass spectroscopic analysis of the resulting fractions established the presence of at least one heptamer of chalcane units.

Keywords
Asparagaceae; Chalcane; Chinese Dragon’s Blood; Dracaena cochinchinensis; Flavonoid; Stilbene.
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