Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor

  • J Nat Prod. 2015 Nov 25;78(11):2841-5. doi: 10.1021/acs.jnatprod.5b00742.
Xueqian He  1 ,  Zhenzhen Zhang  1 ,  Yinghan Chen  1 ,  Qian Che  1 ,  Tianjiao Zhu  1 ,  Qianqun Gu  1 ,  Dehai Li  1
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
PMID: 26561719 DOI: 10.1021/acs.jnatprod.5b00742
Abstract

A new, highly modified fatty acid amide, varitatin A (1), was isolated from the fungus Penicillium variabile HXQ-H-1 cultivated with the DNA Methyltransferase Inhibitor 5-azacytidine. The structure including the absolute configuration of 1 was established by analysis of NMR and MS data, together with chemical degradation and Mosher's method based on MPA esters. Compound 1 showed cytotoxicity against HCT-116 cells with an IC50 value of 2.8 μM and also inhibited the effects of Protein Tyrosine Kinases.