Steroidal Glucosides from the Rhizomes of Tacca chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells

  • Nat Prod Commun. 2016 Jan;11(1):45-8.
Pham Hai Yen ,  Vu Thi Quynh Chi ,  Dong-Cheol Kim ,  Wonmin Ko ,  Hyuncheol Oh ,  Youn-Chul Kim ,  Duong Thi Dung ,  Nguyen Thi Viet Thanh ,  Tran Hong Quang ,  Nguyen Thi Thanh Ngan ,  Nguyen Xuan Nhiema ,  Hoang Le Tuan Anh ,  Chan Van Minh ,  Phan Van Kiem
PMID: 26996017
Abstract

Two new steroidal glucosides, chantriolides D and E (1 and 2), along with four known compounds, chantriolide A (3), chantriolide B (4), chantriolide C (5), and (25S)-spirost-5-en-3-ol 3-O-α-L-rhamnopyranosyl-(1-->2)-O-[α-L-rhamnopyranosyl-(1-->3)]-β-D-glucopyranoside (6) were isolated from the rhizomes of Tacca chantrieri. Their structures were determined by 1D and 2D NMR spectroscopic and HR-ESI-MS data, as well as by comparison with reported data. Compounds 1 and 2 were found to show strong inhibitory NO effect in BV2 cells, with IC₅₀ values of 12.45 and 59.03 µM, respectively.

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