New Alkaloids and α-Glucosidase Inhibitory Flavonoids from Ficus hispida

  • Chem Biodivers. 2016 Apr;13(4):445-50. doi: 10.1002/cbdv.201500142.
Zheng-Feng Shi  1 ,  Chun Lei  1 ,  Bang-Wei Yu  2 ,  He-Yao Wang  2 ,  Ai-Jun Hou  1
Affiliations
  • 1. Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai, 201203, P. R. China.
  • 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, P. R. China.
PMID: 27002475 DOI: 10.1002/cbdv.201500142
Abstract

Two new pyrrolidine Alkaloids, ficushispimines A (1) and B (2), a new ω-(dimethylamino)caprophenone alkaloid, ficushispimine C (3), and a new indolizidine alkaloid, ficushispidine (4), together with the known alkaloid 5 and 11 known isoprenylated Flavonoids 6 - 16, were isolated from the twigs of Ficus hispida. Their structures were elucidated by spectroscopic methods. Isoderrone (8), 3'-(3-methylbut-2-en-1-yl)biochanin A (11), myrsininone A (12), ficusin A (13), and 4',5,7-trihydroxy-6-[(1R*,6R*)-3-methyl-6-(1-methylethenyl)cyclohex-2-en-1-yl]isoflavone (14) showed inhibitory effects on α-glucosidase in vitro.

Keywords
Alkaloids; Ficus hispida; Isoprenylated flavonoids; α-Glucosidase.
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