A trifunctional linker suitable for conducting three orthogonal click chemistries in one pot

  • Org Biomol Chem. 2016 Dec 7;14(45):10576-10580. doi: 10.1039/c6ob02182d.
Astrid-Caroline Knall  1 ,  Manuel Hollauf ,  Robert Saf ,  Christian Slugovc
Affiliations
  • 1. Institute for Chemistry and Technology of Materials, NAWI Graz, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria. [email protected].
PMID: 27786326 DOI: 10.1039/c6ob02182d
Abstract

The feasibility of a one pot approach for conducting mutually orthogonal thiol-Michael addition, copper catalyzed azide-alkyne and inverse electron demand Diels-Alder click chemistry on a tri-functional substrate was demonstrated.

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