Kmeriol and other aromatic constituents of Kmeria duperreana
- Pharm Res. 1989 Jul;6(7):637-40. doi: 10.1023/a:1015969902200.
Affiliations
- 1. Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60680.
PMID: 2798315
DOI: 10.1023/a:1015969902200
Abstract
The CHCl3-soluble fraction of a crude extract of Kmeria duperreana exhibited cytotoxic activity when tested in both KB and P388 tumor-cell cultures. Bioassay-directed fractionation led to the isolation of a cytotoxic alkaloid, liriodenine (1). Other constituents obtained from the extract included scopoletin (2), (-)-3,4,5-trimethoxyphenyl beta-D-glucopyranoside (3), (+)-syringaresinol beta-D-glucopyranoside (4), and a new phenylpropanol, kmeriol (5), whose chemical structure was established through spectroscopic analysis.