30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

  • Cell. 2017 Jan 12;168(1-2):37-57. doi: 10.1016/j.cell.2016.12.012.
Qian Zhang  1 ,  Michael J Lenardo  2 ,  David Baltimore  3
Affiliations
  • 1. Department of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar.
  • 2. Molecular Development of the Immune System Section and NIAID Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: [email protected].
  • 3. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
PMID: 28086098 DOI: 10.1016/j.cell.2016.12.012
Abstract

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.

Keywords
I-κB; NF-κB; Rel; gene regulation; genetic disease; genomics; human gene; immunity; lymphocyte; transactivator.