Two new polyketides from the ascomycete fungus Leptosphaeria sp

  • J Antibiot (Tokyo). 2017 Jun;70(6):743-746. doi: 10.1038/ja.2017.5.
Jie Lin  1 ,  Renlei Wang  1 ,  Guohua Xu  1 ,  Zhengfeng Ding  1 ,  Xueshen Zhu  1 ,  Erwei Li  2 ,  Ling Liu  2
Affiliations
  • 1. Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing, PR China.
  • 2. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.
PMID: 28196973 DOI: 10.1038/ja.2017.5
Abstract

Leptosphaerins H and I (1 and 2), two new xanthone derivatives, and six known compounds, leptosphaerin F (3), monodictysin B (4), norlichexanthone (5), leptosphaerin D (6), moniliphenone (7) and emodinbianthrone (8) have been isolated from a scale-up fermentation of the ascomycete fungus Leptosphaeria sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of 1 was assigned using the modified Mosher method, whereas that of C-8a in 2 was determined via the CD data. Compound 6 showed modest cytotoxicity against a panel of three human tumor cell lines.

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