Three novel indole alkaloids from Kopsia officinalis

  • Fitoterapia. 2017 Jun;119:8-11. doi: 10.1016/j.fitote.2017.01.017.
Zhi-Wei Wang  1 ,  Xiao-Jian Shi  2 ,  Yan Mu  3 ,  Lei Fang  3 ,  Yue Chen  3 ,  Yun-Liang Lin  3
Affiliations
  • 1. Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Shandong Academy of Sciences, 19 Keyuan Street, Jinan, Shandong 250014, China. Electronic address: [email protected].
  • 2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road 501, Shanghai 201203, China.
  • 3. Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Shandong Academy of Sciences, 19 Keyuan Street, Jinan, Shandong 250014, China.
PMID: 28363506 DOI: 10.1016/j.fitote.2017.01.017
Abstract

Three new Indole Alkaloids, named kopsioffines A-C (1-3), possessing relatively novel ten-membered lactam ring, and one known compound (11,12-demethoxy-16-deoxypauciflorine, 4) were isolated from the leaves and stems of Kopsia officinalis. Their structures were elucidated by means of spectroscopic methods. The absolute configuration of 1 was determined by calculated electronic circular dichroism data. The hypothetical biosynthetic pathway of 1 was postulated. All these isolates were evaluated for their inhibitory effects on α-glucosidase. None of them showed activity with IC50 far beyond 50μM.

Keywords
Biosynthetic pathway; Indole alkaloid; Kopsia officinalis.
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