ModelFinder: fast model selection for accurate phylogenetic estimates

  • Nat Methods. 2017 Jun;14(6):587-589. doi: 10.1038/nmeth.4285.
Subha Kalyaanamoorthy  1  2 ,  Bui Quang Minh  3 ,  Thomas K F Wong  1  4 ,  Arndt von Haeseler  3  5 ,  Lars S Jermiin  1  4
Affiliations
  • 1. Land &Water, CSIRO, Canberra, Australian Capital Territory, Australia.
  • 2. Faculty of Pharmacy &Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
  • 3. Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna &Medical University of Vienna, Vienna, Austria.
  • 4. Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
  • 5. Bioinformatics and Computational Biology, Faculty of Computational Science, University of Vienna, Vienna, Austria.
PMID: 28481363 DOI: 10.1038/nmeth.4285
Abstract

Model-based molecular phylogenetics plays an important role in comparisons of genomic data, and model selection is a key step in all such analyses. We present ModelFinder, a fast model-selection method that greatly improves the accuracy of phylogenetic estimates by incorporating a model of rate heterogeneity across sites not previously considered in this context and by allowing concurrent searches of model space and tree space.