How Fast Is Protein-Ligand Association?

  • Trends Biochem Sci. 2017 Nov;42(11):847-849. doi: 10.1016/j.tibs.2017.08.007.
Stefano Gianni  1 ,  Per Jemth  2
Affiliations
  • 1. Istituto Pasteur - Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy. Electronic address: [email protected].
  • 2. Department of Medical Biochemistry and Microbiology, Uppsala University, BMC Box 582, SE-75123 Uppsala, Sweden. Electronic address: [email protected].
PMID: 28917971 DOI: 10.1016/j.tibs.2017.08.007
Abstract

There is increasing interest in studying protein interactions and their role in Cell Biology using kinetics. However, there is confusion about the proper terminology in terms of the distinction between rates and rate constants. We recommend a more stringent use of the words speed, fast, slow, rate, and rate constant.

Keywords
kinetics; ligand; protein binding; protein interactions; rate; rate constant.