CD31 regulates metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway

  • Cancer Lett. 2018 Aug 10;429:29-40. doi: 10.1016/j.canlet.2018.05.004.
Yuan-Yuan Zhang  1 ,  Ling-Qun Kong  2 ,  Xiao-Dong Zhu  1 ,  Hao Cai  1 ,  Cheng-Hao Wang  3 ,  Wen-Kai Shi  1 ,  Man-Qing Cao  1 ,  Xiao-Long Li  1 ,  Kang-Shuai Li  1 ,  Shi-Zhe Zhang  1 ,  Zong-Tao Chai  4 ,  Jian-Yang Ao  5 ,  Bo-Gen Ye  6 ,  Hui-Chuan Sun  7
Affiliations
  • 1. Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, The Key Laboratory for Carcinogenesis and Cancer Invasion, The Ministry of Education of China, Shanghai, 200032, China.
  • 2. Department of Hepatobiliary Surgery, Binzhou Medical College Affiliated Hospital, Binzhou, Shandong, 256603, China.
  • 3. Department of Liver Surgery, Fudan University Cancer Center, Cancer Hospital, Shanghai, 200032, China.
  • 4. Department of Hepatobiliary Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, 200438, China.
  • 5. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
  • 6. Department of Hepatobiliary Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
  • 7. Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, The Key Laboratory for Carcinogenesis and Cancer Invasion, The Ministry of Education of China, Shanghai, 200032, China. Electronic address: [email protected].
PMID: 29746931 DOI: 10.1016/j.canlet.2018.05.004
Abstract

Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a well-known marker of endothelial cells and a key factor for adhesion and accumulation of platelets. CD31 plays roles in cell proliferation, Apoptosis, migration, and cellular immunity. CD31 is also expressed on tumor cells, such as breast Cancer cells and non-Hodgkin's lymphomas, and contributes to tumor cell invasion. Here, our experiments show that CD31 promotes metastasis by inducing the epithelial-mesenchymal transition in hepatocellular carcinoma by up-regulating Integrin β1 via the FAK/Akt signaling pathway.

Keywords
CD31; Epithelial–mesenchymal transition; Hepatocellular carcinoma; Integrin β1; PECAM-1.
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