SYNTHESIS AND OPTICAL RESOLUTION OF HIGH AFFINITY P2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS

  • Tetrahedron Lett. 1995 Jan 23;36(4):505-508. doi: 10.1016/0040-4039(94)02296-N.
Arun K Ghosh  1 ,  Yan Chen  1
Affiliations
  • 1. Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607.
PMID: 30310245 DOI: 10.1016/0040-4039(94)02296-N
Abstract

Racemic bis-tetrahydrofuran ligand 6 was efficiently synthesized utilizing catalytic cobaloxime 10 mediated radical cyclization as the key step. Optical resolution of the racemic alcohol with immobilized-Amano Lipase, afforded optically pure ligands.

Products