Veluflavanones A-P, Cytotoxic Geranylated Flavanones from Dalbergia velutina Stems

  • J Nat Prod. 2019 Feb 22;82(2):276-282. doi: 10.1021/acs.jnatprod.8b00688.
Sutin Kaennakam  1 ,  Edwin Risky Sukandar  1 ,  Pongpun Siripong  2 ,  Kitiya Rassamee  2 ,  Santi Tip-Pyang  1
Affiliations
  • 1. Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science , Chulalongkorn University , Bangkok , Thailand , 10330.
  • 2. Natural Products Research Section , National Cancer Institute , Bangkok , Thailand , 10400.
PMID: 30719909 DOI: 10.1021/acs.jnatprod.8b00688
Abstract

Sixteen new geranylated flavanones, named veluflavanones A-P (1-16), and a known analogue (17), were isolated from Dalbergia velutina. The chemical structures of 1-17, as well as their absolute configurations, were determined by spectroscopic analysis and experimental ECD data. All isolated compounds were tested for their cytotoxicity against five human Cancer cell lines. Compound 9 showed cytotoxicity toward KB, HeLa S3, and MCF-7 cells with IC50 values of 9.9, 8.1, and 10.0 μM, respectively. In addition, compounds 10, 11, 14, and 16 exhibited selective cytotoxicity against HeLa S3 cells with IC50 values of 6.6-9.9 μM.