Mass production of poly(ethylene glycol) monooleate-modified core-shell structured upconversion nanoparticles for bio-imaging and photodynamic therapy

  • Sci Rep. 2019 Mar 26;9(1):5212. doi: 10.1038/s41598-019-41482-w.
Xingyuan Zhang  1  2 ,  Zhao Guo  2  3 ,  Xiao Zhang  4 ,  Linji Gong  2  3 ,  Xinghua Dong  3 ,  Yanyan Fu  5 ,  Qing Wang  6  7 ,  Zhanjun Gu  2  3
Affiliations
  • 1. Institute of Nano Engineering, College of Civil Engineering and Architecture, Shandong University of Science and Technology, Qingdao, 266590, China.
  • 2. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
  • 3. University of Chinese Academy of Sciences, Beijing, 100049, China.
  • 4. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. [email protected].
  • 5. State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China. [email protected].
  • 6. Institute of Nano Engineering, College of Civil Engineering and Architecture, Shandong University of Science and Technology, Qingdao, 266590, China. [email protected].
  • 7. School of Material Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China. [email protected].
PMID: 30914696 DOI: 10.1038/s41598-019-41482-w
Abstract

Developing robust and high-efficient synthesis approaches has significant importance for the expanded applications of upconversion nanoparticles (UCNPs). Here, we report a high-throughput synthesis strategy to fabricate water-dispersible core-shell structured UCNPs. Firstly, we successfully obtain more than 10 grams core UCNPs with high quality from one-pot reaction using liquid rare-earth precursors. Afterwards, different core-shell structured UCNPs are fabricated by successive layer-by-layer strategy to get enhanced fluorescence property. Finally, the hydrophobic UCNPs are modified with poly(ethylene glycol) monooleate (PEG-OA) though a novel physical grinding method. On the basis of mass-production, we use the as-prepared PEG-UCNPs to construct an 808-nm stimuli photodynamic therapy agent, and apply them in Cancer therapy and bio-imaging.

Products