Cytotoxic Pregnane Steroidal Glycosides from Chonemorpha megacalyx

  • J Nat Prod. 2019 Jun 28;82(6):1542-1549. doi: 10.1021/acs.jnatprod.9b00013.
Fang-Yu Yuan  1 ,  Xiao-Ling Wang  2 ,  Tian Wang  1 ,  Tao Shen  1 ,  Dongmei Ren  1 ,  Hongxiang Lou  1 ,  Xiao-Ning Wang  1
Affiliations
  • 1. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , 44 West Wen-Hua Road , Jinan 250012 , People's Republic of China.
  • 2. The Second Hospital of Shandong University , 247 Bei-Yuan Street , Jinan 250033 , People's Republic of China.
PMID: 31148449 DOI: 10.1021/acs.jnatprod.9b00013
Abstract

Three new C21 pregnane Steroids, chonemorphols A-C (1, 3, and 4), 11 new C21 steroidal glycosides, chonemorphosides A-K (2 and 5-14), and 11 known compounds (15-25) were obtained from the vines and leaves of Chonemorpha megacalyx Pierre. Their structures were established using extensive spectroscopic data. The X-ray crystallographic data of 1 and 3 permitted definition of their absolute configurations. Notably, 1 and 2 possessed an uncommon 6/5/6/5/5-fused steroidal ring system. Compound 7 displayed significant cytotoxicity against several Cancer cell lines with IC50 values of 2.0-3.6 μM.