17- nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei

  • J Nat Prod. 2019 Jun 28;82(6):1565-1575. doi: 10.1021/acs.jnatprod.9b00059.
Zhan-Peng Ge  1  2 ,  Hong-Chun Liu  1 ,  Guo-Cai Wang  1 ,  Qun-Fang Liu  1 ,  Cheng-Hui Xu  1 ,  Jian Ding  1 ,  Yao-Yue Fan  1 ,  Jian-Min Yue  1  2
Affiliations
  • 1. State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • 2. University of Chinese Academy of Sciences , No. 19A Yuquan Road , Beijing 100049 , People's Republic of China.
PMID: 31184894 DOI: 10.1021/acs.jnatprod.9b00059
Abstract

Seventeen new 17- nor-cephalotane-type Diterpenoids, fortalpinoids A-Q (1-17), were isolated from the seeds of Cephalotaxus fortunei var. alpine. Compound 12 represents the first 17- nor-cephalotane-type diterpenoid featuring an 8-oxabicyclo[3.2.1]oct-2-ene moiety. The absolute configuration of fortunolide A (18) was determined for the first time, and the structure of cephinoid Q was revised to 14- epi-cephafortoid A (24) by X-ray crystallographic data analysis. Some of the compounds showed significant cytotoxicity against A549 and HL-60 cells, and the structure-activity relationship of this compound class is discussed.