Avoiding raising the ire of IRE1α

  • Cell Calcium. 2019 Nov:83:102056. doi: 10.1016/j.ceca.2019.102056.
Luis B Agellon  1 ,  Marek Michalak  2
Affiliations
  • 1. School of Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, H9X 3V9, Canada. Electronic address: [email protected].
  • 2. Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2S7, Canada. Electronic address: [email protected].
PMID: 31437638 DOI: 10.1016/j.ceca.2019.102056
Abstract

IRE1α is well known as a regulator of one branch of the UPR pathway that is activated during ER stress that operates to regain ER proteostasis. In a recent paper, Carreras-Sureda et al. show that IRE1α is also a structural component of MAMs and facilitates the uptake of CA2+ by mitochondria.

Keywords
Calcium signaling; Endoplasmic reticulum stress; IRE1; Membrane contact sites; Mitochondria.